Airline revenue down $29 billion. Auto sales in China cratering. Supply chains snapped.

The coronavirus outbreak, whose breadth and duration remains a disquieting question mark, is forcing international companies across nearly every industry to face a stark reality: Business will not go on as usual.

And investors have taken notice. U.S. stocks fell for the second straight day on Friday, with the S&P closing more than 1 percent lower, putting it on pace for its worst day of the month. Oil and gas prices also fell.

Auto sales in China collapsed this month, with the Chinese Passenger Car Association saying that sales at dealerships had plummeted 92 percent in the first half of February compared with the same period last year. China is the world’s biggest car market by a wide margin, so a nose-dive in sales causes pain.

The International Air Transport Association this week warned of a deep drop in earnings of about $29 billion this year among global carriers, with virtually all of the losses expected to hit airlines in the Asia-Pacific region.