As deaths from the novel coronavirus topped 1,000 — nearly all of them in China — Beijing on Tuesday urged countries that have enacted travel restrictions aimed at curbing the outbreak to restore normal ties for the sake of the global economy. The appeal from China’s Foreign Ministry underscored the economic dangers posed by the unprecedented shutdown of much of the world’s second-largest economy, as well as the ruling Communist Party’s concerns about the outbreak’s capacity to fuel domestic instability.

Authorities in the virus-hit city of Wuhan have announced fresh restrictions on residents, making millions of people virtual prisoners in their own homes. Two provincial health bosses have been fired as the Communist Party struggles to contain widespread anger over the spread of the virus. Here’s what we know:

● The death toll from the new coronavirus surged above 1,000 in mainland China, with more than 100 deaths in a single day, a record. The number of confirmed infections continues to rise, but the rate of growth is slowing.

● China urged countries around the world to soon restore normal ties, warning that if its economy suffers, so will that of the rest of the world.

● Authorities in Wuhan tightened restrictions on citizens, allowing just one member of a household to make one shopping trip every three days and placing entire buildings under quarantine.

● More than a dozen ambulances lined up alongside the Diamond Princess in Yokohama as medical staff evacuated passengers and crew infected with the virus, after 65 more people on board the cruise ship tested positive.

● China is bracing for the return of some 160 million migrant workers to their cities of employment as the country’s economy sputters back to life after an extended holiday following the outbreak.